細(xì)胞松弛素B是一種可滲透細(xì)胞的真菌毒素，它與肌動(dòng)蛋白的倒刺端結(jié)合，可逆地抑制肌動(dòng)蛋白絲的伸長和縮短。[1]通過破壞肌動(dòng)蛋白聚合，細(xì)胞松弛素B阻斷不同的細(xì)胞功能，包括細(xì)胞分裂、遷移、吞噬作用、胞吐作用、趨化性和葡萄糖轉(zhuǎn)運(yùn)。[2，3，4]細(xì)胞松弛素B廣泛用于細(xì)胞學(xué)研究，包括依賴于肌動(dòng)蛋白聚合的許多過程中的任何一個(gè)。[5，6，7]

產(chǎn)品性質(zhì)：

Cas No.：14930-96-2

別名：細(xì)胞松弛素B; Phomin

Canonical SMILES： O=C1N[C@@H](CC2=CC=CC=C2)[C@@]3([H])[C@]14[C@](/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(O4)=O)([H])[C@H](O)C([C@H]3C)=C

分子式：C29H37NO5

分子量：479.61

溶解度：DMSO: ≥ 100 mg/mL (208.50 mM); Ethanol: 25 mg/mL (52.13 mM)

儲(chǔ)存條件：Store at -20°C

注意事項(xiàng)：

為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。

References:

[1]Theodoropoulos, P.A., Gravanis, A., Tsapara, A., et al.Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end cappingBiochem. Pharmacol.47(10)1875-1881(1994) [2].Steinberg, M.S., and Wiseman, L.L.Do morphogenetic tissue rearrangements require active cell movements? The reversible inhibition of cell sorting and tissue spreading by cytochalasin BJ. Cell Biol.55606-615(1972)

[3].Spudich, J.A., and Lin, S.Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement/microfilaments/rabbit striated muscle)Proc. Natl. Acad. Sci. USA69(2)442-446(1972) [4].Estensen, R.D., and Plagemann, P.G.W.Cytochalasin B: Inhibition of glucose and glucosamine transportProc. Natl. Acad. Sci. USA69(6)1430-1434(1972)

[5].Snezhko, A., Barlan, K., Aranson, I.S., et al.Statistics of active transport in Xenopus melanophores cellsBiophys. J.993216-3223(2010)

[6].Yu, Y., Dumollard, R., Rossbach, A., et al.Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturationJ. Cell. Physiol.224(3)672-680(2010)

[7].Yu, Y., Maguire, T.G., and Alwine, J.C.Human cytomegalovirus activates glucose transporter 4 expression to increase glucose uptake during infectionJ. Virol.85(4)1573-1580(2011)